牡丹种子化学成分研究

Chemical constituents from seeds of Paeonia suffruticosa

目的：进一步研究牡丹Paeonia suffruticosa种子中化学成分。方法：采用硅胶、ODS及Sephadex LH-20等柱色谱进行分离,通过理化常数和波谱分析鉴定化合物的结构。结果：分离得到13个化合物,分别鉴定为芍药苷（1）、氧化芍药苷（2）、6′-O-β-D-葡萄糖芍药内酯苷（3）、8-去苯甲酰芍药苷（4）、8-debenzoylpaeonidanin（5）、1-O-β-D-glucopyranosylpaeonisuf-frone（6）、1-O-β-D-乙基甘露糖苷（7）、蔗糖（8）、木犀草素（9）、芹菜素（10）、苯甲酸（11）、1-O-β-D-对羟基苯甲酰葡萄糖苷（13）。结论：化合物2,4~6为该种首次分离得到,化合物7和12为首次从芍药科植物中分离得到。

Objective：To study the chemical constituents from seeds of Paeonia suffruticosa.Method：Various chromatographic techniques were used to isolate and purify the constituents,their physico-chemical properties and spectral data were employed to elucidate their structures.Result：Thirteen compounds were isolated and identified as： paeoniflorin（1）,oxypaeoniflorin（2）,6′-O-β-D-glucopyranosylalbiflorin（3）,8-debenzoylpaeoniflorin（4）,8-debenzoylpaeonidanin（5）,1-O-β-D-glucopyranosylpaeonisuffrone（6）,1-O-β-D-ethyl-mannopyranoside（7）,sucrose（8）,luteolin（9）,apigenin（10）,benzoic acid（11） and 1-O-β-D-（4-hydroxybenzoyl）glucose（12）.Conclusion：compounds 2,4-6 were isolated from this plant for the first time,compounds 7 and 12 were isolated from the family of Paeoniaceae for the first time.