孕期亚临床甲状腺功能减退对胎儿及儿童发育的影响及相关机制

Effect and Related Mechanisms of Subclinical Hypothyroidism during Pregnancy on the Development of Fetus and Children

孕期亚临床甲状腺功能减退影响胎儿及儿童发育,主要表现在神经心理、妊娠结局及行为等方面,其中神经心理发育包括脑、智力和认知发育;不良妊娠结局有低出生体质量、早产及宫内发育迟缓;不良行为表现包括焦虑/抑郁,注意力问题和攻击行为综合征等。现从甲状腺素的角度出发,介绍孕期亚临床甲状腺功能减退对胎儿及儿童发育的影响及相关机制。

Subclinical hypothyroidism during pregnancy do harm to fetal and children development,including neuropsychology,pregnancy outcome and behavior development. Neuropsychological development contains brain,mental and cognitive development. The adverse pregnancy outcomes are low birth weight, prematurity and intrauterine growth retardation;Adverse behaviors are anxiety/depression, attention problems and aggressive behavior syndrome, etc. In the view of thyroid hormone, the fact that the mechanisms which subclinical hypothyroidism during pregnancy affects the development of fetal and child are introduced in this article.