摘要
三羟基核苷因其具有良好的抗病毒性能及作为核酸代谢作用的抑制剂而受到人们的关注.文献报道的合成方法[1~3]因反应需避光,温度控制要求严格,中间体二醛不稳定[4],给操作带来困难.产物不易纯化,一般局限于使用离子交换色谱法[5],而按此方法得到的无环核...
Title compounds were obtained by treating nucleosides with two antagonistic polymeric reagents, P IO - 4 and P BH - 4 in one pot process. The method has the advantages of simple operation , mild reaction condition and unnecessary isolation of the intermediates with high yield.
出处
《应用化学》
CAS
CSCD
北大核心
1999年第1期83-85,共3页
Chinese Journal of Applied Chemistry
关键词
三羟基核苷
聚合物试剂
合成
trihydroxy nucleoside,polymeric reagent,synthesis