(1′S,4R,5R)-2-(1′-溴乙基)-2-(5-溴-6-甲氧基-2-萘基)-1,3-二氧戊环-4,5-二羧酸的不对称合成

Asymmetric Synthesis of (1′S,4R,5R) 2 (1′ Bromo ethyl) 2 (5 bromo 6 methoxy 2 naphthyl) 1,3 dioxolane 4,5 dicarboxylic Acid

萘普生［（Ｓ）２（６甲氧基２萘基）丙酸］是一种非常重要的非麻醉性消炎镇痛药．周宏英等［１］报道了用手性膦配体ＤＤＰＰＩ对２（６甲氧基２萘基）乙醇进行不对称羰基化反应合成了萘普生甲酯．本文用（２Ｒ，３Ｒ）酒石酸二甲酯为手性辅助剂，以...

Title compound was synthesized with total yield of 80% by acetalization, asymmetric bromination, hydrolysis of 6 methoxy 2 propionylnaphthalene, using(2R,3R) dimethyl tartrate as a chiral auxiliary.