体外受精-胚胎移植后异位妊娠45例分析

Analysis of 45 Ectopic Pregnancy After in Vitro Fertilization and Embryo Transfer

目的:探讨体外受精-胚胎移植(IVF-ET)后异位妊娠(EP)的高危因素。方法:对接受体外受精(IVF)、单精子卵胞浆内注射(ICSI)、冻融胚胎移植(FET)助孕后发生异位妊娠病例的助孕指征、助孕方式、异位妊娠类型等进行回顾分析。结果:1771新鲜助孕周期(IVF-ET,ICSI),417个冷冻周期(FET),1025个周期临床妊娠,其中宫内妊娠980个周期,妊娠成功率46.8%,异位妊娠45个周期(宫内宫外同时妊娠3个周期),异位妊娠发生率为2.06%:其中输卵管因素实施IVF-ET后发生异位妊娠37个周期,占82.22%。年龄、移植胚胎个数与本次助孕后异位妊娠的发生无关(P>0.05)。结论:IVF输卵管因素是异位妊娠发生的高危因素,移植管距宫底位置、取卵数、移植前内膜厚度与EP的发生有关。

Objective：To investigate the risk of ectopic pregnancy after in vitro fertilization and embryo transfer （IVF-ET）. Methods： This study retrospectively analysed the indications, methods of assisted conception of the ectopic pregnancy （EP） after IVF-ET and intracytoplasmic sperm injection and embryo Transfer （ISCI-ET） and frozen-thawing embryo transfer. Results： A total of 1771 embryo transfers were performed from June 2007 to June 2009 in Tang Du hospital ,and 1025 clinical pregnancies were obtained and 45 were ectopic pregnancies （Including 3 cases of heterolopic pregnancy HP）. The occurrence rate was 2. 06%. Among all ectopic pregnancies,the assisted conception of 37 cases was tubal pathology and/or pelvic adherence （82. 22% ）. Conclusion： Tubal disease and pelvic adhesions are high-risk factors when ectopie pregnancy occurred. The deep of Transfertubal tip to uterine fundus, average number of eggs and endometrial thickness were closely concerned with ectopic pregnancy rate.