水凝胶修饰生物兼容性电极

Hydrogel-Modified Bio-Electrodes

由于高分子水凝胶独特的柔软性、生物相容性和仿生特性,采用水凝胶修饰电极降低了电极的峰间噪声水平,克服了目前生物传感器在生物兼容性和组织-电极间相互作用方面的局限性。本文结合近年来国内外的最新研究进展,综述了涂渍法、共价键合法、电化学法和层层自组装法等水凝胶修饰电极的几种主要制备方法,较为全面地总结了水凝胶修饰电极在神经元电极、酶修饰电极、氧化还原蛋白修饰电极、pH传感器及其他方面的应用,最后对水凝胶修饰电极研究面临的挑战和未来的发展进行了讨论。

Hydrogels offer attractive properties,such as unique softness,biocompatibility and biomimetic performance.Electrodes modified with hydrogels would decrease peak-to-peak noise signals and overcome the limitation of present biosensors in biocompatibility and tissue-to-electrode interaction.In this paper,recent advances on hydrogel-modified electrodes are reviewed.Current preparation methods of hydrogel-modified electrodes are summarized,including dip-coating,covalent binding,electrochemistry and layer-by-layer selfassembly.Furthermore,an overview is given for the applications of hydrogels in neural electrodes,enzymemodified electrodes,redox protein-modified electrodes,pH sensors and other sensors.Finally,the challenges and promising developments of hydrogel-modified electrodes are prospected.