维生素E琥珀酸酯诱导肿瘤细胞凋亡作用机制的研究进展

Research Progress about the Mechanisms of Vitamin E Succinate-induced Apoptosis of Cancer Cells

维生素E琥珀酸酯是维生素E的衍生物。维生素E琥珀酸酯对肿瘤细胞有显著的凋亡杀伤作用,而对正常细胞没有明显的毒性反应。维生素E琥珀酸酯诱导肿瘤细胞凋亡的机制主要有线粒体途径、脂肪酸合成酶信号系统、MAPK途径、蛋白激酶C等途径。这些机制的研究发现可以为开发出新型与VES抗肿瘤作用同一靶分子的抗肿瘤药物开辟新途径。

Vitamin E Succinate（VES） is the derivate of vitamin E.VES can effectively inhibit many kinds of tumors without toxic effects on normal cells and tissues.There are many aspects about the mechanism of VES-induced apoptosis of cancer cells：Mitochondria pathway,Fas pathway TGF-pathway,MAPK pathway and PKC pathway.These discoveries may contribute to develop a new kind of antineoplastic drug that shares the same target molecule with VES.