高良姜总黄酮对胃肠运动的影响研究

Effect of Total Flavonoids from Alpinia officinarum on Gastrointestinal Motility

目的:研究高良姜总黄酮对胃肠运动的影响。方法:采用胃排空法观察高良姜总黄酮对正常小鼠胃排空和溴吡斯的明所致小鼠胃排空亢进的影响;通过离体实验观察高良姜总黄酮对大鼠胃平滑肌的影响;用小肠推进法观察高良姜总黄酮对小鼠小肠运动的影响。结果:高良姜总黄酮对正常小鼠胃排空无显著影响,而对溴吡斯的明所致小鼠胃排空亢进有显著拮抗作用(P<0.01或P<0.05);对乙酰胆碱引起的大鼠胃平滑肌痉孪有显著抑制作用(P<0.01);对正常小鼠小肠运动有显著抑制作用,可明显减少推进距离,降低推进率(P<0.05)。结论:高良姜总黄酮能显著抑制胃肠运动。

OBJECTIVE： To study the effect of total flavonoids from Alpinia officinarum on gastrointestinal motility.METHODS： Gastric emptying method was applied to observe the effect of total flavonoids from A.officinarum on gastric emptying of normal mice and sthenic gastric emptying induced by pyridostigmine bromide.Effect of total flavonoids from A.officinarum on gastric smooth muscle of rats was observed through in vitro test and small intestine advancement was used to observe the influence of total flavonoids from A.officinarum on intestinal motility.RESULTS： Total flavonoids from A.officinarum had no significant influence on gastric emptying of normal mice,but distinctly inhibited sthenic gastric emptying induced by pyridostigmine bromide（P0.01 or P0.05）.And it also significantly inhibited gastric smooth muscle spasm of rats（P0.01）.Total flavonoids from A.officinarum significantly inhibited intestinal motility of normal mice and reduced advance distance and advance rate（P0.05）.CONCLUSION： Total flavonoids from A.officinarum can distinctly inhibit gastrointestinal movement.