脾脏窦岸细胞血管瘤5例病理分析

Analysis about the pathology of 5 cases of littoral cell angioma of spleen

目的:探讨脾窦岸细胞血管瘤的临床表现和病理特征。方法:收集脾窦岸细胞血管瘤5例进行临床表现和光镜及免疫组化检查。结果:脾窦岸细胞血管瘤组织学表现为瘤组织由大小不等的窦样腔隙构成,腔壁上伴有突向腔内的乳头状结构,腔隙壁及乳头状增生突起的表面均衬以单层内皮样细胞,免疫组化显示瘤细胞呈双重分化即内皮细胞及组织细胞标记物均呈阳性。结论:脾窦岸细胞血管瘤是良性血管性肿瘤,临床表现无特异性,其发现主要靠影像学检查,诊断则需靠病理组织学及免疫组化确诊。

Objective：To investigate the clinical and pathological feature of the littoral cell angioma （LCA） of spleen.Methods：Five patient with littoral cell angioma were analyzed by the clinical data and checked by histopathology and immunohistochemistry.Results：The clinical feature of 5 littororal cell angioma were atypitcal.There is a mammilliform structure pointing inside in the wall of the lacune.The lacune wall and the surface of the mammilliform structure are both based on monolayer vascular endothelium-like cells.Immunohistochemistry indicates that tumor cell is double differentiated,which can also be explained that both of the markers of vascular endothelium-like cells and tissue cells are positive.Conclusion：LCA is a healthy angioma.The clinical feature of littororal cell angioma was atypitcal.The main way to find LCA of spleen is the image examination.It＇s diagnosis is on the basis of microscopic and immunohistochemical.