胃癌患者血清肿瘤标志物水平与临床病理学特征的关系

The correlation between serum levels of tumor markers and clinical pathological characteristics in gastric cancer patients

目的 探讨胃癌患者术前血清肿瘤标志物CEA、CA125、CA19-9的水平与临床病理学特征的关系.方法 采用电化学发光免疫分析法检测107例胃癌患者术前血清中CEA、CA125、CA19-9水平.结果 胃癌患者血清中CEA、CA125、CA19-9水平与性别、年龄及肿瘤发生部位之间均无密切相关.有淋巴结转移的胃癌患者血清中CEA、CA125、CA19-9水平高于无淋巴结转移的胃癌患者.CEA、CA125、CA19-9水平随浸润程度加深及肿瘤的增大而增高.分化程度越低,CA125水平越高,而CEA、CA19-9水平与分化程度无显著相关性.胃癌患者血清中CA125、CEA、CA19-9三者之间存在正相关,CA125与CA19-9相关系数为0.623（P〈0.01）,CA125与CEA相关系数为0.572（P〈0.01）,CA19-9与CEA相关系数为0.412（P〈0.01）.结论 胃癌患者血清中CEA、CA125、CA19-9水平与胃癌病灶的大小、浸润深度及有无淋巴结转移等显著相关,且血清中CA125、CEA、CA19-9三者之间存在正相关性,故术前检测血清中三者的水平能够为胃癌患者治疗方案的制订提供一定的参考.

Objective To investigate the relationship between the serum levels of CEA,cAl25,CA19-9 and clinical pathological characteristics in gastric cancel patients.Method The serum levels of CEA,CA125 and CA19-9 in 107 gastric cancer patients before the surgery were detected by electrochemiluminescence immunoassay.Results The preoperative seurm levels of CEA,CA125 and CA19-9 were not correlated with sex,age and the location of the tumor.The serum level of CEA,CA125 and CA19-9 in patients with lymph node metastasis were higher than those in patients without lymph node metastasis.The serum levels of CEA,CA125 and CA19-9 were positively correlated with the depth of tumor invasion and the size of the tumor.The serum levels of CA125 were correlated with the degrees of differentiation.Thehigher the CA125 levels,the lower the degrees of differentiation.But the levels of CEA and CA19-9 were not correlated with differentiation.There were positive.correlations among the serum levels of CEA,CA125 and CA19-9.The correlation coefficient of CA125 and CA19-9 was 0.623（P〈0.01）,CA125 and CEA was 0.572（P〈0.01）,CA19-9 and CEA was 0.412（P〈0.01）.Conclusions The serum levels of CEA,CA125 and CA19-9 in gastric cancer patients are significantly related with the size of the tumor,the depta of tumor invasion and lymph node metastasis.The preoperative serum levels of CEA,CA125 and CA19-9 can provide some reference for formulating the treatment of the gastric cancer patients.