血清孕酮预测异位妊娠MTX治疗疗效的研究

Serum progesterone prediction of ectopic pregnancy MTX curative effect

目的探讨血清孕酮(P)水平在异位妊娠保守治疗中成功率预测的价值。方法回顾分析2008年11月至2009年11月期间符合异位妊娠保守治疗条件的78例患者进行研究,对成功与失败的病例对比分析血清P与人体绒毛膜促性腺激素(β-HCG),并以孕酮(P)20、30、40、50和60nmol/ml为临界值进行计算,计算可作为预测治疗成功与失败的血清孕酮参考值。结果①成功与失败组血清β-HCG值比较差异无统计学意义(P>0.05);血清孕酮比较差异有统计学意义(P<0.05);②根据灵敏度及特异度推荐血清孕酮40nmol/ml作为区分异位妊娠MTX治疗成功与失败的临界值。结论结合血清β-HCG,血清P是预测异位妊娠治疗效果的良好指标,优于单一血清β-HCG。

Objective To explore serum progesterone（P）levels in ectopic pregnancy rate predicted in the conservative treatment.Methods Reviewed on November 2008~2009 November period with ectopic pregnancy conservative treatment of 78 cases patients condition,the case of success and failure analysis P and serum,and β-HCG with progesterone（P）20,30,40,50 and 60 nmol/ml for critical were computed and can be treated as prediction success and failure of serum progesterone reference.Results ①The success and failure group β-HCG value were not statistically significant（P 0.05）,progesterone is statistically significant（P 0.05）;②sensitivity and specificity according to recommend serum progesterone 40 nmol/ml as divisional ectopic pregnancy MTX critical success and failure treatment.Conclusion Combined with serum β-HCG,serum P is forecast of ectopic pregnancy outcomes than single index,good β-HCG