胸腺肽对不同月龄雌性小鼠血清激素水平的影响

Effects of Thymosin on Serum Hormone Levels in Female Mice of Different Ages (Months)

通过分别给1月龄和3月龄雌性小鼠连续30d皮下注射不同剂量的胸腺肽,研究胸腺肽对血清中促卵泡激素(FSH)、雌二醇(E2)、促甲状腺激素(TSH)和胰岛素(INS)水平的影响。结果表明,各剂量胸腺肽使1月龄小鼠血清FSH、E2水平显著或极显著降低(P<0.05,P<0.01);TSH水平显著或极显著升高(P<0.05,P<0.01);INS水平降低,其中高剂量组INS水平显著降低(P<0.05)。各剂量胸腺肽使3月龄小鼠血清FSH水平降低,其中高剂量组FSH水平显著降低(P<0.05);TSH水平升高,其中高剂量组TSH水平极显著升高(P<0.01);E2、INS水平降低,但差异不显著。可见,胸腺肽能影响雌性小鼠血清激素水平,从而调节雌性小鼠的内分泌系统。

After 30 days＇ subcutaneous injection of different doses of thymosin into the female mice of different ages （1 month,3 months）,serum hormone levels of Follicle-Stimulating Hormone （FSH）,Estradiol-2 （E2）,Thyroid-Stimulating Hormone （TSH） and Insulin （INS） were detected to determine the effects of thymosin.The results show that for 1 month mice with different doses of thymosin,FSH and E2 levels are decreased significantly or very significantly （P〈0.05,P〈0.01）,TSH levels are increased significantly or very significantly （P〈0.05,P〈 0.01）,INS levels are decreased,and high dose thymosin makes a significant difference in INS （P0.05）.For 3 month mice with different doses of thymosin,FSH levels are decreased and high dose thymosin makes a very significant difference in FSH （P〈0.01）,TSH levels are increased and high dose thymosin makes a significant difference in TSH （P〈0.05）.E2 and INS levels are decreased with no significant difference.It is concluded that thymosion influences female mice＇s serum hormone level,which in turn affects its endocrine system.