雷公藤多甙联合福辛普利治疗儿童肾病综合征型紫癜性肾炎疗效分析

Tripterygium wilfordii polypeptide combined fosinopril treatment of children with nephrotic syndrome Henoch-Schonlein purpura nephritis

目的观察雷公藤多甙联合福辛普利治疗儿童肾病综合征型紫癜性肾炎的治疗效果。方法2006年12月至2009年12月在我院儿科就诊的38例诊断为肾病综合征型紫癜性肾炎的患儿，分别将患儿随机分为治疗组20例（口服雷公藤多甙联合福辛普利）和对照组18例（口服雷公藤多甙），观察药物对两组患儿水肿、高血压、血尿、蛋白尿的疗效，采用SPSS10．0软件进行统计学分析。结果治疗组完全缓解18例（90％），部分缓解2例（10％）。对照组完全缓解11例（61％），部分缓解6例（39％），无效1例（6％）两组缓解率比较，差异无显著性（P〉0．05），但治疗组水肿消退、血压恢复正常、血尿消失、尿蛋白转阴的平均时间均明显短于对照组，差异有显著性（P〈0．01）。结论雷公藤多甙联合福辛普利治疗儿童肾病综合征型紫癜性肾炎疗效优于单用雷公藤多甙，值得临床应用。

Objective To observe tripterygium wilfordii polypeptide（TWP） combined fosinopril treatment of children with nephrotic syndrome treatment of Henoch-Schonlein purpura nephritis. Methods from December 2006 to December 2009 in our hospital pediatric clinic, 38 patients were diagnosed as nephrotic syn- drome in children with Henech-Schonlein Purpura nephritis, respectively, were randomly divided into treatment group（20 eases of oral TWP joint Fosinopril）and control group, 18 patients（ oral TWP） , observation of drugs on two groups of children with edema, hypertension, hematuria, proteinuria efficacy, using SPSS10. 0 software for statistical analysis. Results The complete remission in 18 cases （90%）, partial remission in 2 cases （ 10% ）. Control group, complete remission in 11 cases（61% ）, partial remission in 6 cases（39% ）, ineffective in 1 （6%）remission rate of the two groups, the difference was not significant（ e 〉 0. 05 ）, but the treat- ment group edema subsided, blood pressure returned to normal, hematuria disappeared, urine protein was negative on average were significantly shorter than the control group, the difference was significant （ P 〈 0. 01 ）. Conclusion The effect of TWP combined fosinopril treatment of children with nephrotic syndrome Henoch- Schonlein purpura nephritis is better than TWP alone and it is worth clinical application.