用(R)-(+)-缩水甘油的亲核开环反应制备手性连二醇

Synthesis of Chiral Nonracemic Vicinal Diols Via Nucleophilic Rhig - Opening of (R)-( + )- Glycidol

以D-甘露醇为原料合成(R)-(+)-缩水甘油1。该环氧化合物的亲核开环反应为高立体选择性地(93％～96％e.e.)制备各种手性连二醇提供了一条简便途径。

(R) - ( + ) - Glycidol 1 was synthesized from D - mannitol. Nucleophilic ring - opening of this epoxide gave a convenient method for generation a variety of chiral nonracemic vicinal diols in high stereoselectivity (93% -96% e.e.).