O-(3-三苯锗基)正丙基硫代磷酸酯及类似物的合成

Synthesis of O-(3-triphenylgermyl)propyl phosphorothioates and Their Derivatives

首次采用３－三苯锗基正丙醇及其衍生物笔硫代磷酸类的合成路线，合成了１３个标题新化合物，其结构由ＩＲ、ＨＮＭＲ及ＭＳ等手段鉴定，研究结果表明：以ＮａＨ作缚酸剂，１８－冠－６作相转移催化剂可以大大加速反应，体外实验表明，部分化合物对ＫＢ，Ａ２７８０。

Thirteen titled compounds were synthesized by the reaction of O - alkyl - O - aryl phosphochloridothioates with 3 - (triphenylgermyl) - 1 - propanols. Their structures were confirmed by IR, 1H NMR, MS and elementary analyses. The reaction can be accelerated by addition of phase transfer catalysts and the best results were obtained in the presence of 18 - crown - 6. Some of these compounds showed antitumor activities in vitro .