摘要
A new preparation method of the sustained-releasing microspheres containing acetamiprid was developed with carboxymethyl chitosan and acacia as base materials.The preparation condition were optimized using L16(45) orthogonal experimental design with the drug encapsulation and the shape of the microspheres as criteria.As a result,the optimum preparation conditions of the microspheres were as follows:the concentration ratio of carboxymethyl chitosan to acacia was 1∶3,the dosage of acetamiprid was 1.0 g,the amount of 10 % glutaraldehyde was 16mL.The complex coacervation reation was conducted at 45 ℃ for 80min.The experimental results showed that there were no chemical interactions between acetamiprid and the carboxymethyl chitosan/acacia complex and a good drug releasing performances of the acetamiprid microspheres was obtained.
A new preparation method of the sustained-releasing microspheres containing acetamiprid was developed with carboxymethyl chitosan and acacia as base materials.The preparation condition were optimized using L16（45） orthogonal experimental design with the drug encapsulation and the shape of the microspheres as criteria.As a result,the optimum preparation conditions of the microspheres were as follows：the concentration ratio of carboxymethyl chitosan to acacia was 1∶3,the dosage of acetamiprid was 1.0 g,the amount of 10 % glutaraldehyde was 16mL.The complex coacervation reation was conducted at 45 ℃ for 80min.The experimental results showed that there were no chemical interactions between acetamiprid and the carboxymethyl chitosan/acacia complex and a good drug releasing performances of the acetamiprid microspheres was obtained.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2010年第6期745-748,共4页
Chemical Research and Application
基金
河北省科学技术研究与发展计划结转项目(07220701D-5)资助
河北农业大学非生命学科与新兴学科科研发展基金项目资助
关键词
啶虫脒
羧甲基壳聚糖
阿拉伯胶
缓释/控释
acetamiprid
carboxymethy chitosan
acacia
delayed release/controlled release
