摘要
The C-C coupling reaction between ethyl acetoacetate and aryl iodides,catalysted by CuI,in the presence of N-methyl glycine under microwave irradiation in DMSO was studied.It afforded an efficent protocol to synthesis arylated acetoacetate ester.Microwave irradiation reduced reaction times obviously.Most interestingly,as the changing of bases and prolonging of reaction times,deacylated and decarboxy ester reaction resulted in succession.
The C-C coupling reaction between ethyl acetoacetate and aryl iodides,catalysted by CuI,in the presence of N-methyl glycine under microwave irradiation in DMSO was studied.It afforded an efficent protocol to synthesis arylated acetoacetate ester.Microwave irradiation reduced reaction times obviously.Most interestingly,as the changing of bases and prolonging of reaction times,deacylated and decarboxy ester reaction resulted in succession.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2010年第6期782-785,共4页
Chemical Research and Application
关键词
微波
芳基乙酸酯
碘代芳烃
偶联反应
microwave irradiation
arylated acetoacetate ester
aryl iodides
coupling reaction
