糖尿病因素对医院感染特征的影响

Impact of diabetes mellitus on characteristics of nosocomial infection

目的分析糖尿病因素对医院感染特征的影响。方法选择2006年7月-2008年6月某院内科医院感染病例为研究对象,以是否存在糖尿病因素分为研究组(有糖尿病)和对照组(无糖尿病),分析两组基础疾病、感染部位、易感因素、侵袭性因素和病原菌分布情况的异同。结果研究组较少合并肿瘤疾病(P=0.00),较多发生泌尿道感染(P=0.00,OR=1.61),较少有化学治疗(P=0.01)、使用肾上腺糖皮质激素(P=0.00)和免疫抑制剂(P=0.01)易感因素,较多进行血液透析(P=0.00,OR=2.82)和发生肠球菌属感染(P=0.01,OR=2.06)。结论糖尿病因素对医院感染特征有一定影响,提示在关注所有医院感染易感因素时,对于糖尿病患者尤其要注重血液透析的管理和预防肠球菌泌尿道感染的发生。

Objective To explore the impact of diabetes mellitus （DM） on characteristics of nosocomial infection （NI）. Methods Patients with NI in a hospital between July, 2006 and June, 2008 were selected as studied subjects, and patients were divided into studied group （patients with DM） and control group （patients without DM）, the similarities and differences in underlying diseases, infection sites, susceptible factors, invasive factors and pathogenic distribution between two groups were analysed. Results In studied group, fewer patients complicated with tumor （P = 0. 00） ,more with urinary tract infection （P = 0. 00,OR = 1.61）, the use of chemotherapy （P = 0. 01）, glucocorticoid （P = 0. 00） and immunosupressive agents （P = 0. 01） were infrequent, more patients received blood dialysis （P=0.00, OR=2.82） and developed Enterococcus infections （P=0.01, OR=2.06）. Conclusion There are certain impact of DM on characteristics of NI. The management of blood dialysis in patients with DM should be intensified and prevention of urinary tract Enterococcus infection should be paid attention.