摘要
目的探讨连续性肾替代治疗(CRRT)对多脏器功能不全综合征(MODS)患者肠道菌群的影响。方法选取我院重症监护病房(ICU)住院的MODS患者40例,分为对照组和CRRT组,分别给予危重病常规治疗和在此基础上加用CRRT,1周后比较2组治疗前后肠道菌群菌落计数和比例的变化。结果与对照组相比,CRRT组肠球菌、肠杆菌数量显著减少,而双歧杆菌、乳酸杆菌数量和厌氧菌总数显著升高(P<0.05);同时双歧杆菌/肠杆菌和厌氧菌总数/需氧菌总数的比值显著升高(P<0.05)。结论 CRRT有助于改善MODS患者的肠道菌群失调。
Objective To study the influence of continuous renal replacement therapy（CRRT）on intestinal flora in patients with multiple organ dysfunction syndrome（MODS）.Method Forty inpatients with MODS in ICU were divided into two groups randomly.The two groups were treated with routine therapy and routine therapy plus CRRT respectively.The intestinal flora and the ratio of flora were compared between the two groups.Results Compared with the group of routine therapy,in the group of routine therapy plus CRRT,the enterococcus and the enterobacter were decreased significantly.While the bifidobacterium and the lactobacillus were increased significantly（P0.05）.The anaerobic bacteria was increased significantly,the aerobic bacteria was decreased significantly（P0.05）,in the routine therapy group compared with that in routine therapy plus CRRT group.Meanwhile the ratios of bifidobacterium and enterobacter were increased significantly（P0.05）,and the ratios of anaerobic bacteria to aerobic bacteria were increased（P0.05）.Conclusion CRRT may improve alteration of intestinal flora in the patients with MODS.
关键词
肾替代疗法
多脏器功能不全综合征
肠道菌群
Renal replacement therapy
Multiple organ dysfunction syndrome
Intestinal flora
