摘要
目的:探讨参附强心合剂对心衰大鼠血流动力学的影响。方法:采用腹主动脉缩窄法制做心衰大鼠模型,颈动脉插管法通过生物信号采集系统收集各项参数,观察参附强心合剂对心衰大鼠血流动力学的作用。结果:参附强心合剂各剂量组和西药组均能升高LVSP、+dp/dtmax、-dp/dtmax、Vmax,降低LVEDP,心功能的各项指标较模型对照组明显改善(P<0.05)。中药各治疗组与西药对照组比较无明显差异(P>0.05)。结论:参附强心合剂具有改善慢性心衰血流动力学指标及保护心脏的作用。
Objective：To investigate the influence of Shenfuqiangxin（SFQX） decoction on haemodynamics in chronic heart failure （CHF） rats. Methods：Using male adult SD rats made CHF models by coarctation of abdominal aorta（CAA）. LVSP ＋dp/dtmax -dp/dtmax Vmax and LVEDP were measured through the tube inserted into the carotid artery and analysed by the MED-labU/4C system software. To observe the change of haemodynamics. Results：The heart function were obvionsly improved in SFQX decoction big、morderate,small dose group,and the western medicine group compared with the model control group：LVSP,＋dp/dtmax,-dp/dtmax,Vmax were increased and the LVEDP was decreased（P0.05）.However there were no difference among 4 drug treated groups. Conclusion：SFQX decoction could significantly improve haemodynamics and protect heart.
出处
《中华中医药学刊》
CAS
2010年第6期1125-1127,共3页
Chinese Archives of Traditional Chinese Medicine
基金
杭州市科技局立项课题(LX2007)
关键词
参附强心合剂
心力衰竭
血流动力学
Shenfuqiangxin decoction
chronic heart failure
haemodynamics
