接骨丹胶囊急性毒性与长期毒性实验研究

Experimental Research on the Acute Toxicity and Long-term Toxicity of Jiegudan Capsule

目的:对接骨丹胶囊的急性和长期毒性进行研究,观察接骨丹胶囊的毒副作用。方法以健康昆明种小鼠和SD大鼠为对象,急性毒性实验将20只小鼠给接骨丹胶囊5.0g·kg-1,一次灌胃,连续给药1周。长期毒性实验将80只大鼠随机分为4组,分大、中、小给药剂量组(分别给接骨丹胶囊内容物3g、1g、0.5g·kg-1)和对照组(给生理盐水1mL.100g-1)。接骨丹胶囊内容物制成混悬溶液,均为灌胃给药。结果:小鼠1天内灌胃给接骨丹胶囊最大耐受量≥5.0g/kg,给药组与对照组检查指标,结果统计分析均无明显差异(P>0.05)。结论:灌胃给接骨丹胶囊对小鼠,大鼠均无明显的毒性反应。

Objective：To research the acute toxicity and long-term toxicity of the Jiegudan Capsule and observe its toxicity sidi-effect. Methods：healthy kunming species mice and SD species rats were picked out. First,having an acute toxicity test,5.0g·kg^-1Jiegudan Capsule,were given to 20 pcs mice,ehema one time,continuous giving medicine one week. 80 pcs rats were given long-term toxicity test and divided into 4 groups,big small little group （were given Jiegudan Capsule 0.5g,1g,3g·kg^-1separately） and control group （were given physiological saline 1mL·100g^-1）. Jiegudan Capsule should be made into water reagent. All the animals were given medicine in ehema. Results：The oral maximal tolerance dose of Jiegudan Capsule in mice was more than 5.0g·kg^-1 There was no significant difference between the testgroups and the control in all tested parameters.Conclusion：The Jiegudan Capsule have no obviously toxicity,so suggest that Jiegudan Capsule is safe for clinical application.