12种常用抗肿瘤药物对肝癌敏感性试验结果分析

目的比较12种常用抗肿瘤药物对原发性肝癌（HCC）药敏试验结果，探索肝癌化疗的合理用药。方法取95例HCC患者术中活体肝癌组织癌细胞与12种常用抗肿瘤药物共同培养：紫杉醇（FIX）49例，阿霉素（ADM）50例，平阳霉素（BLM）50例，环磷酰胺（CTX）59例，甲胺喋呤（MTX）16例，5-Fu95例，表阿霉素（ADM）90例，顺铂（DDP）90例，丝裂霉素（MMC）57例，吉西他宾（GEM）88例，奥沙利铂（OXA）58例，羟基喜树碱（HCPT）51例。以MTr法检测各种药物对HCC细胞抑制率，〈30％为不敏感，30％～60％为低度敏感，61％～90％为中度敏感，〉90％为高度敏感。结果不敏感药物有紫杉醇、阿霉素、平阳霉素、环磷酰胺、甲胺喋呤；低度敏感有5-Fu；中度敏感有丝裂霉素、奥沙利铂、羟基喜树碱、吉西他宾、表阿霉素、顺铂；高度敏感0。各组之间敏感差异性有统计学意义（P〈0．05）。结论本试验结果提示5-Fu为低度敏感药物，不宜作为常规用药，可选择敏感度较高的丝裂霉素、奥沙利铂。肝癌化疗药物最好根据药物敏感试验结果选择。

Objective Screening reasonable chemotherapeautic agents for hepatic cell carcinoma （HCC） from 12 anticancer drugs. Method HCC cell obtained from operation was co - cultured with 12 chemotherapeautic agents： PTX for 49 cases. ADM for 50 cases, BLM for 50 cases, CTX for 59 cases, MTX for 16 cases ,5 - Fu for 95 cases, ADM for 90 cases, DDP for 90 cases, MMC for 57 cases, GEM for 88 cases , OXA for 58 cases , HCPT for 51 cases, MTr method was used as cancerous sensitivity exams. Inhabiting rate of 〈 30%, 30% - 60%, 60% - 90%, 〉 90% was classified as non - sensitive, low - sensitive, middle - sensitive and high - sensitive, comparing the sensitivity in same group and between groups. Result Groupl （ non - sensitive ） includes PTX, ADM, BLM, CTX, MTX ; group2 （ low - sensitive） only 5 - Fu, group3 （ middle - sensitive） are MMC, OXA, HCPT, GEM, ADM, DDP. Group4 （ high sensitivity ） none. There was statistics among the three groups（ P 〈 0.05 ） but no significant difference with a single group in same group （ P 〉 0. 05 ）. Conclusion It is unreasonable to choose 5 - Fu as chemotherapeautic agent as usual, MMC,OXA, HCPT, GEM, ADM, DDP are better to choose for the chemotherapeautic agents , result of drug sensitive test should be considered when choosing chemotherapeautic agents for treating HCC.