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12种常用抗肿瘤药物对肝癌敏感性试验结果分析 被引量:5

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摘要 目的比较12种常用抗肿瘤药物对原发性肝癌(HCC)药敏试验结果,探索肝癌化疗的合理用药。方法取95例HCC患者术中活体肝癌组织癌细胞与12种常用抗肿瘤药物共同培养:紫杉醇(FIX)49例,阿霉素(ADM)50例,平阳霉素(BLM)50例,环磷酰胺(CTX)59例,甲胺喋呤(MTX)16例,5-Fu95例,表阿霉素(ADM)90例,顺铂(DDP)90例,丝裂霉素(MMC)57例,吉西他宾(GEM)88例,奥沙利铂(OXA)58例,羟基喜树碱(HCPT)51例。以MTr法检测各种药物对HCC细胞抑制率,〈30%为不敏感,30%~60%为低度敏感,61%~90%为中度敏感,〉90%为高度敏感。结果不敏感药物有紫杉醇、阿霉素、平阳霉素、环磷酰胺、甲胺喋呤;低度敏感有5-Fu;中度敏感有丝裂霉素、奥沙利铂、羟基喜树碱、吉西他宾、表阿霉素、顺铂;高度敏感0。各组之间敏感差异性有统计学意义(P〈0.05)。结论本试验结果提示5-Fu为低度敏感药物,不宜作为常规用药,可选择敏感度较高的丝裂霉素、奥沙利铂。肝癌化疗药物最好根据药物敏感试验结果选择。 Objective Screening reasonable chemotherapeautic agents for hepatic cell carcinoma (HCC) from 12 anticancer drugs. Method HCC cell obtained from operation was co - cultured with 12 chemotherapeautic agents: PTX for 49 cases. ADM for 50 cases, BLM for 50 cases, CTX for 59 cases, MTX for 16 cases ,5 - Fu for 95 cases, ADM for 90 cases, DDP for 90 cases, MMC for 57 cases, GEM for 88 cases , OXA for 58 cases , HCPT for 51 cases, MTr method was used as cancerous sensitivity exams. Inhabiting rate of 〈 30%, 30% - 60%, 60% - 90%, 〉 90% was classified as non - sensitive, low - sensitive, middle - sensitive and high - sensitive, comparing the sensitivity in same group and between groups. Result Groupl ( non - sensitive ) includes PTX, ADM, BLM, CTX, MTX ; group2 ( low - sensitive) only 5 - Fu, group3 ( middle - sensitive) are MMC, OXA, HCPT, GEM, ADM, DDP. Group4 ( high sensitivity ) none. There was statistics among the three groups( P 〈 0.05 ) but no significant difference with a single group in same group ( P 〉 0. 05 ). Conclusion It is unreasonable to choose 5 - Fu as chemotherapeautic agent as usual, MMC,OXA, HCPT, GEM, ADM, DDP are better to choose for the chemotherapeautic agents , result of drug sensitive test should be considered when choosing chemotherapeautic agents for treating HCC.
出处 《浙江临床医学》 2010年第6期564-565,共2页 Zhejiang Clinical Medical Journal
关键词 原发性肝癌 化疗药物 敏感性 HCC 12 anticancer agents sensitivity
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