单核细胞趋化蛋白-1在慢性阻塞性肺疾病患者发病中的作用探讨

The induced sputum and serum levels and significance of monocyte chemoattractant protein-1 in patients with COPD

目的探讨单核细胞趋化蛋白-1(MCP-1)在慢性阻塞性肺疾病(COPD)发病机制中的作用。方法 COPD住院患者38例,入院后达稳定期时分别抽取静脉血用酶联免疫吸附试验法(ELISA)测定诱导痰和血清的MCP-1水平,行BODE评分,选取性别、年龄相配的35例健康人为正常对照,评价两组间的MCP-1水平的差别。结果 COPD组诱导痰及血清MCP-1水平均高于正常对照组。COPD患者诱导痰及血清MCP-1水平与BODE评分呈正相关,与FEV1呈负相关。结论 MCP-1可能参与了COPD气道炎症和重构的发生发展,与患者的预后密切相关。

Objective To investigate the pathophysiologic roles of monocyte chemoattractant protein-1（MCP-1） in chronic obstructive pulmonary disease（COPD）.Methods 38 patients with COPD were enrolled,while 35 gender-and age-matched healthy subjects served as a normal control.Pulmonary function test and BODE score were performed.MCP-1 levels in serum and induced sputum were assayed at the stable stage.Results The induced suptum and serum levels of MCP-1 in the COPD group were both higher than those in the normal control group.The induced sputum and serum levels of MCP-1 in patients with COPD were both negatively correlated with FEV1 and positively correlated with BODE score.Conclusion MCP-1 might contribute to the airway inflammation and renmdeling in COPD,and have close correlation with the prognosis of COPD.