苄星青霉素治疗妊娠期梅毒的研究

Study on treatment of benzathine penicillin on syphilis in pregnancy

目的评价苄星青霉素治疗妊娠期梅毒的疗效。方法对成都市第三人民医院和木里县人民医院2000年1月-2009年12月期间妊娠合并梅毒患者的临床资料进行回顾性分析。根据是否用苄星青霉素行抗梅毒治疗,将妊娠合并梅毒患者分为治疗组与对照组。结果 10年间医院分娩总人数10682例,妊娠合并梅毒患者81例,发生率9.2‰。治疗组与对照组新生儿死亡率分别为0.0%及12.5%,先天梅毒分别为8.33%及55.60%,死胎发生率为0.0%及23.3%。结论妊娠期梅毒是严重危害围产儿的合并症,孕期有效的苄星青霉素治疗,可有效降低围产儿死亡率及先天性梅毒的发生。

Objective To study the efficacy of benzathine penicillin in treatment of pregnant women with syphilis.Methods Patients with syphilis in pregnancy were collected and analyzed,retrospectively.Pregnant women with syphilis were divided into treatment group and control group depending on whether they received anti-syphilis treatment with benzathine penicillin or not.Results There were 81 pregnancy women with syphilis in 10,682 pregnancy.The incidence was 9.2‰.The neonatal death rates in the treatment group and control group were 0 and 12.5%,congenital syphilis were 8.33% and 55.60%,stillbirth rates were 0 and 23.3%,respectively.Conclusion Syphilis during pregnancy is a serious hazard perinatal complications.Benzathine penicillin treatment is effective,which can reduce the perinatal mortality and the incidence of congenital syphilis.