缺氧诱导因子-1α在宫颈癌中的表达及意义

Expression and Significance of HIF-1α in Uterine Cervix Cancer

目的探讨缺氧诱导因子-1α(HIF-1α)在宫颈癌发生发展过程中蛋白表达情况。方法应用免疫组织化学S-P方法检测HIF-1α在正常宫颈组织(NCE)20例、宫颈上皮内瘤变组织(CIN)28例、宫颈癌(ICC)组织70例中的表达情况。结果在正常宫颈上皮、宫颈上皮内瘤变组织、宫颈癌(I-IIA期)组织中,HIF-1α蛋白的阳性表达率分别是0、32.14%、72.86%(P<0.01)。结论 HIF-1α的表达与宫颈癌的发生发展密切相关,促进宫颈癌的发生发展。

Objective To investigate the expression of HIF-1α during the carcinogenesis and development of cervical carcinoma. Methods Immunohistochemistry technique（SP method）was employed to detect expression of HIF-1α in tissues from 20 cases of normal cervical epithelium（NCE）,28 cases of cervical intraepithelial neoplasia（CIN）and 70 cases of invasive carcinoma of cervix （ICC）. Results The positive rates of HIF-1α protein expression in NCE, CIN and ICC tissues were 0,32.14%, 72.86%（P〈0.01）. Conclusion Expression of HIF-1α displays a positive correlation and is closely related with the carcinogenesis and development of cervical carcinoma. HIF-1α protein promotes the development of cervical carcinoma.