幽门螺杆菌感染与胃癌发生的相关性

RELATIONSHIP BETWEEN HELICOBACTER PYLORI INFECTION AND GASTRIC CARCINOGENESIS

目的：探讨胃粘膜幽门螺杆菌感洒与人胃癌（ＨＧＣ）发生的相关性。方法：采用斑点金免疫渗滤试验，快速尿素酶试验、ＰＣＲ－Ｈｐ－ＤＮＡ法检测胃粘Ｈｐ。方法：对１４１例慢性胃炎患者和４２例胃癌患者在ＨＰ现症感染的检测。结果：慢性浅表性胃炎、轻度萎缩性胃炎ＨＰ感染率较高，非贲门癌血抗Ｈｐ－ＩｇＧ阳性率较贲门癌高，ＨＰ感染者胃粘膜萎缩，肠化及癌变平均年龄较小，结论：ＨＰ持续感洒与ＨＧＣ。

Objective:To study the relationship between helicobacter pylori(Hp) infection and gastric carcinogenesis.Methods:Dot immunogold filtration assay,rapid urease test and PCR-Hp-DNA were used to detect Hp present infection in 141 cases of chronic gastritis and 42 cases of gastric carcinoma (GC).Results:The detection rate of Hp infection was higer in subjects with chronic superficial gastritis or chronic atrophic gastitis than in subjects with GC.The detection rate of serum anti-Hp-IgG antibody in non-cardiac GC was higher than that in cardiac GC.Hp-negative patients with chronic atrophic gastritis,intestinal metaplasia or GC had more advanced average ages than those Hp-positive patients.Conclusions:Hp infection is associated with gastric carcinogenesis,especially intestinal type non-cardiac gastric carcinogenesis.It may be one of the “promotors” in the course of gastric carcinogenesis.