胃腺癌组织中Fas,Bcl—2蛋白表达及其与浸润转移关系的研究

STUDY ON THE RELATIONSHIP BETWEEN THE EXPRESSION OF Fas、Bcl-2 AND THE INFILTRATION AND METASTASIS OF GASTRIC CANCER

目的：为了解Ｆａｓ、Ｂｃｌ－２蛋白在胃腺癌中的表达及其意义。方法：用免疫组化ＡＢＣ法检测４８例胃腺癌中Ｆａｓ、Ｂｃｌ－２蛋白的表达。结果：中、高人化癌中Ｆａｓ蛋白了性表达率（７０．６％、７１．４％）显著高于低分化癌（１２．５％），无淋巴结转移组的胃癌Ｆａｓ阳性表达率（５５．６％）高于有淋巴结转移组，浸及粘膜衣粘膜下的胃癌Ｆａｓ阳性表达率（７１．４％）高于浸及浆膜及周围组织者（２３．５％）。

To study the role of Fas and Bcl-2 in gastric cancer,Using avidin-biotin complex (ABC) technique,we examined the expression of Fas.Bcl-2 in 48 specimens of gastric cancer.The results are as follows:The positive rates of Fas in mediated-diffenentiated and well-differentiated groups (70.6%、71 4% respectively) was higher than that in poorly-differentiated group(12.5%),(P<0.05),it was higher in nonmetastasis group (55.6%) than that in the metastasis group (23.6%),(P<0.05),it was higher in invasion of mucosa and submucosa (71.4%) than tht in serosa and surrounding tissues (23.5%),(P<0.05).The positive rates of Bcl-2 in well-diffterentiated group (42.8%) was higher than that in poorly-differentiated group (87.5%),(P<0.05).The expression of Bcl-2 was not related to either the depth of invasion or lymph-node metastasis.These suggest that there may be a positive correlation between the expression of Fas and differentiated,infiltration and lymph-metastesis of gastric cancer and there may be a positive correlation between the expression of Bcl-2 and differentiated.