As_2O_3对胃癌的黏附分子、VEGF、nm23表达的影响

Expression Effect of Adhesion Molecules,nm23 and CD_(44) in Gastroinetstinal Cancer As_2O_3

目的本实验通过观察胃癌术前短时间,小剂量As2O3应用,探讨As2O3对胃癌的E-CD、VEGF、nm23、CD44表达变化的影响。方法分别在手术前给8例确诊为胃癌的患者As2O3治疗3d。在用药前和术中提取患者的病理组织。利用免疫组织化学法检测8例胃癌组织中的E-CD、VEGF、nm23、CD44表达情况。结果应用三氧化二砷注射液化疗后与用药前比较,肿瘤组织中E-CD、VEGF、CD44表达下调,nm23表达上调。结论体内实验证实,三氧化二砷的抗肿瘤作用与下调CD44、VEGF,上调nm23有关,抑制肿瘤的浸润与转移而起到抑制肿瘤的作用。

Objective Though the short preoperative observation of stomach carcinoma,and the expression changes’ effects of E-CD,VEGF,nm23 and CD44 by using low-dose As2O3,this experiment discuss the effi cacy of preoperative chemotherapy by using As2O3. Method 8 patients diagnosed as gastrointestinal cancer are given As2O3 treatment respectively for three days before surgery. Extract the patients’ pathological tissues pre-administration and during operation and use immunohistochemistry methods to detect the expression changes’ effects of E-CD,VEGF,nm23 and CD44 in 8gastrointestinal cancer tissues. Results E-CD,VEGF and CD44 express down-regulation nm23 express up-regulation. Conclusion Preliminary confirmation,As2O3＇s antitumor effect related to down-regulation of VEGF and CD44 and op-regulation of nm23.It inhibits the tumor＇s infi ltration and metastasis.