脐血清胰岛素样生长因子-I的检测意义

Serum Concentration of Insulin-like Growth Factor-Ⅰ in Cord Blood

为了评估胰岛素样生长因子－Ｉ（ＩＧＦ－Ｉ）在胎儿、胎盘生长发育中的作用，用放射免疫分析法（ＲＩＭ）测定了脐血清 ＩＧＦ－Ｉ的浓度。结果显示：脐血清 ＩＧＦ－Ｉ在ＳＧＡ组、ＡＧＡ组、ＬＧＡ组分别为（９０．８０± ４９．００）μｇ／Ｌ、（１４４． ５９± ４６． ７３）μｇ／Ｌ、（２０９． １７± ８１．４５）μｇ／Ｌ。与 ＡＧＡ组比较，ＳＧＡ组脐血清 ＩＧＦ－Ｉ浓度显著减低（ ｔ＝ ４．７７， Ｐ＜０．０１），ＬＧＡ组显著升高（ｔ＝７．９７，Ｐ＜０．０１）。说明ＩＧＦ－Ｉ是胎儿胎盘生长发育的重要调节因子，对巨大儿、小样儿的形成有重要作用。

To evaluate the role of insulin-like growth factor-I(IGF-I)in fetal growth and Placental growth, cord blood IGF-I was detained by radioimmunoassay(RlA ) after serum Samples were extracted with acid-ethanol. The mean serum levels of IGF-l in the small-for gestationd-age(SGA), average-for-gestational-age (AGA), large-for-gestational-age (LGA) neonates were(90. 80 ±49. 00)μg/L, (144. 59±46. 73 )μg/L, (209. 17 ± 81. 45)μg/L resistively. The mean serum levels of IGF- I in the SGA neonates were significantly lower than those in AGA neonates(t =4. 77, P<0. 01). But the serum concen- trations of IGF-I in the LGA neonates were significantly higher than those of AGA neonates(t = 7. 97, P<0. 01). These results suggested that IGF-I was an important regulator of fetal and placental growth and development. It had the key role for macrosomia and IUGR forming.