慢性肺心病合并铜绿假单胞菌肺炎21例分析

Analysis of Pseudomonas Aeruginosa Pneumonia in 21 Cases with Chronic Pulmonary Heart Disease

分析我院呼吸科近５年慢性肺心病合并铜绿假单胞菌肺炎住院患者的临床特点、细菌培养结果及药敏试验。结果显示：慢性肺心病合并铜绿假单胞菌肺炎的发病率高，占同期肺心病下呼吸道感染的第２位（１５．４４％，２１／１３６例）。病情重且迁延，易反复发作，细菌清除率低（１４．２８％）。该菌对氨苄西林、氨苄西林／青霉烷砜、头孢噻吩、头孢唑啉、头孢呋肟、头孢呋肟脂、头孢西丁及呋喃妥因耐药。对妥布霉素、替卡西林、替卡西林（克拉维酸）、伊米配能高度敏感；对阿米卡星、庆大霉素、环丙沙星、头孢他啶、头孢哌酮、氨曲南、哌拉西林、羧苄西林及美洛西林敏感。提示治疗应选用敏感抗生素，对重症宜联合用药以防止耐药菌株的发生。

To analyze the clinical manifestations , bacterial culture and antibiotic susceptibilities to P. aeruginosa Pneumonia of 21 cases who had been hospitalized with chronic pulmonary heart disease in recent's five years. Results showed that morbidity of Patients with P. aeruginosa Pneumonia was second(15. 44% ) among the total infections in the same Pened. The Patient condition was Serious and the course of disease Protracted, they had attacks repetedly. Bacterial clearance rate was low (14. 28% ). The strains of P. aeruginosa were resistant to ampicillin, ampicillin-sullbactam, cephalothin, cephalin, cefu- rokime, cefokitin and nitroftirantoin. And the strains of P. aeruginosa were susceptible to tobramycin, ticarcillin,ticarcillin- clav ulanic acid, imipenem, amikacin, gentamicin, ciprofloxacin, ceftazidime, cefoperazone, atreonam, Piperacillin, Carbencillin and mezlocillin.