摘要
目的：检测claudin－4与E—cadherin在胃癌中的表达，探讨其表达的意义及关系。方法：本实验以180例胃癌标本作为研究对象，50例正常胃粘膜组织作为对照，应用流式细胞术分析，分别检测claudin-4与E—cadherin的表达，分析其在不同临床病理特征中的表达意义。结果：claudin－4与E—cadherin在胃癌中的表达均明显低于正常胃粘膜组织，claudin－4与E—cadherin在不同肿瘤直径、不同浸润深度及有无淋巴结转移的比较中，差别有统计学意义。胃癌中claudin-4与E—cadherin的表达呈正相关。结论：claudin－4与E—cadherin参与胃癌的发生发展，联合检测可能对判断预后有一定价值。
Objective： To detect the expressions of claudin -4 and E - cadherin protein, investigate their significance and relationship in gastric carcinoma. Methods： The study included 180 cases of gastric carcinoma as observation group and 50 cases of normal gastric mucosa as control group. We detected the expressions of claudin -4 and E -cadherin in different clinical characters by FCM. Results： The expressions of claudin -4 and E - cadherin were lower in the gastric carinoma than in control group. Comparisons of the control group, the expressions of claudin -4 and E -cadherin were correlated with tumor volume, invasion depth and lymph node metastasis. There were posi- tive relationship between the claudin - 4 and E - eadherin in the neoplasm. Conclusions ： The abnormal expressions of claudin - 4 and E - cadherin may promote the occurrence and development in gastric carcinoma. The joint detection of claudin - 4 and E - cadherin should be helpful to predict the prognosis in gastric carcinoma.
