复聪片对老年大鼠蜗内神经结构影响的实验研究

THE EFFECTS OF FUCONG TABLET ON THE NEURAL ELEMENTS IN COCHLEAE OF AGED RATS

为探讨复聪片防治老年性聋的机制，以老年大鼠疆孔内神经纤维和螺旋神经为观察指标，发现复聪片能有效支持上述蜗内神经结构。提示蜗内神经结构的退变可能是老年性聋的主要病理基础。复聪片支持蜗内神经结构可能基于如下途径：１）促进神经生长因子与其受体的结合；２）通过保护毛细胞，间接促进神经生长因子的产生。

The purpose of the shtudies was to explore the therapeutic mechanism of Fucong Tablet on the presbycusis.The nerve fibers in habenula perforta and spiral ganglion of aged rats were obsered.The results indicated that Fucong Tablet could effectively support the neural elements.It suggested that the damages of neural elements in cochleae should be the major reason for presbycusis.The maintenance of the neural elements should be related with the effects of Fucong Tablet as flowing:1)Promoting the nerve growth factor (NGF) to combine with its receptor.2)Protecting hair cells to produce indirectly neuraltrophin.