美他多辛作用的研究

Study on Effects of Metadoxine

目的:因美他多辛对乙醇性肝病的生化机理有积极作用,同时用于急性和慢性乙醇中毒、乙醇性肝病,但该药的致突变作用未见报道,本文在于检测美他多辛致突变性。方法:通过微生物回复突变试验、小鼠微核试验、哺乳动物培养细胞染色体试验证明。结果:美他多辛的三个试验结果均呈阴性。结论:美他多辛在用于治疗急性和慢性乙醇中毒、乙醇性肝病无致突变性。

Objective： for Metadoxine ethanol-induced liver disease on the biochemical mechanism has a positive effect for both acute and chronic alcohol intoxication, alcohol-induced liver disease, but the role of drug-induced mutations have not been reported in this paper is to test Metadoxine mutagenicity. Methods microbial reverse mutation assay, mouse micronucleus test, chromosome test to prove mammalian cell culture. Results Metadoxine of three test results were negative. Conclusion Metadoxine used for the treatment of acute and chronic alcohol intoxication, alcohol-induced liver disease nonmutagenic.