摘要
研究了拉西地平(1)与聚乙烯吡咯烷酮(PVP)共沉淀物的制备,考察了1与不同比例的PVP共沉淀物胶囊的药物累积溶出度,结果表明,1-PVP(1∶5)共沉淀物胶囊的累积溶出度明显高于同比例物理混合物胶囊及司乐平片。
The coprecipitates of lacidipine (1) with different ratios of PVP were prepared, and the
accumulated dissolution of its capsules were explored. The satisfactory ratio of 1∶ PVP was 1∶5
and the accumulated dissolution of the capsules was distinctly higher than those of capsules of
physical mixture of 1 PVP(1∶5) and commercial Si Le Ping tablets.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1999年第3期116-118,共3页
Chinese Journal of Pharmaceuticals
关键词
拉西地平
聚乙烯吡咯烷酮
共沉淀物
溶出度
lacidipine,
polyvinylpyrrolidone, coprecipitate, capsules, accumulated dissolution