氧氟沙星涂膜剂的制备及质量控制

PREPARATION AND QUALITY CONTROL OF OFLOXACIN PAINT

以壳聚糖、甘油为辅料，制备了氧氟沙星涂膜剂。实验表明，该制剂质量控制可行，符合有关要求。采用紫外分光光度法测定其含量，线性范围３．６０～７．２０μｇ／ｍｌ，平均回收率９９．９６％，ＲＳＤ为０．７１％。

Using chitosan and glycerin as the excipients, ofloxacin paint was prepared, and its quality control was established. The content of ofloxacin was determined by UV spectrophotometry at wavelenth of 293nm, the linear range was 3.6～7.2μ g/ml. The average recovery was 99.96% with RSD of 0.71%.