摘要
Foxp3+调节性T细胞在免疫反应和免疫耐受中具有识别自我、"准自我"和非自我的关键作用,是当前免疫学领域的热点问题。Treg的转录因子Foxp3的发现和功能性报告鼠的研究进展揭示了Treg群体和功能的多样性。Treg亚型的分析有助于认识Treg细胞分化动力学、正常状态与疾病状态互动,并通过操纵特殊Foxp3+亚型调控免疫应答。虽然大量体外研究强调了效应T细胞的终末定向,现渐明确的是T细胞定向更具易变性。就起源而论也许最具易变的T细胞亚型是Tfh细胞,主要来源于肠集合淋巴小结和促使B细胞产生抗体IgA,对维持肠道免疫内隐态平衡起重要作用。
A pivotal role of Foxp3^＋ regulatory T cells is control of immune responses to self,＂quasi-self＂and non-self,which is an active issue in the area of immunology.The discovery of FoxP3 as a key Treg transcription factor combined with recent advances in the development of functional reporter mice has shown a new insights into diversity of Tregs and revealed unexpected features of this lineage.The dissection of FoxP3^＋ cells into subsets contribute to analyze Treg cell differentiation dynamics and interactions in normal and disease states,and to control immune responses through manipulating particular FoxP3^＋ subpopulations.Although past studies that were largely carried out in vitro emphasized terminal commitment of effector T cells,it has now become clear that flexibility in T cell commitment is probably not the exception,but rather the norm.Tfh cells are mostly defined by their follicular localization in mouse Peyer′s patches and promote IgA production which play an pivotal role for intestinal immune homeostasis.
出处
《医学综述》
2010年第12期1798-1801,共4页
Medical Recapitulate
