子宫内膜异位症发病机制的研究进展

Research Progress in the Pathogenesis of Endometriosis

子宫内膜异位症(EM)发病机制的研究表明,经血逆流是诱因,"黏附-侵袭-血管形成"是EM病灶形成的病理生理过程。EM的发生是在位内膜的特质性决定的;免疫功能异常、多种细胞活性因子在EM的发生发展中起了重要的作用,所以提出了在位内膜学说、免疫学说及遗传学说等,从不同的方面阐述了EM的发病机制。现就EM的发病机制的研究进展进行综述,为寻求更新更完善的治疗方法提供思路。

Researches show that menstrual blood reflux is the incentive of endometriosis and the attachment-aggression-angiogenesis is the basic pathogenesis of EM.Some studies have suggested that the occurrence of EM depends on the eutopic endometrium and the immune dysfunction in combination with a variety of cell activity factors plays an important role in the occurrence and development of EM.Therefore,multiple theories of EM pathogenesis are proposed from different perspectives,including eutopic endometrium theory,immune theory and genetic theory.This paper reviewed the pathogenesis of EM in order to search for new comprehensive treatments.