学龄前肥胖儿童硬脂酰辅酶A去饱和酶的变化

Changes of stearoyl coenzyme A desaturase in preschool children with obesity

目的：观察学龄前肥胖儿童血浆单不饱和脂肪酸（monounsaturated fatty acids,MUFAs）水平及硬脂酰辅酶A去饱和酶（stearoyl-CoA desaturase,SCD）活性的变化,探讨其与体重指数（body mass index,BMI）之间的关系。方法：选取36例3~6岁的单纯性肥胖儿童并按性别、年龄1∶1配对的36例正常儿童。利用气相色谱分析方法测定其血浆脂肪酸组成,以棕榈油酸/棕榈酸（C16∶1n-7/C16∶0）比值代表SCD活性。结果：肥胖儿童血浆棕榈油酸、油酸（C18∶1n-9）、MUFA总量及SCD活性较正常儿童均显著升高（P〈0.05）;相关性分析显示,肥胖儿童SCD活性与BMI呈显著正相关关系（P〈0.05）。结论：SCD活性及MUFAs水平升高在肥胖发生中可能起着一定的作用,但具体情况尚有待进一步探讨。

Objective：To observe the changes of plasma monounsaturated fatty acids（MUFAs）level and activity of stearoyl coenzyme A desaturase（SCD）,and explore their relationship with body mass index（BMI）in preschool children with obesity.Methods：36 obese children and 36 normal children aged 3～6 years old were selected according to 1∶1 pairing of gender and age.The composition of plasma fatty acids was detected by gas chromatographic analysis,the ratio of palmitoleic acid/palmitic acid（C16∶1n-7/C16∶0）represented the activity of SCD.Results：The total amounts of plasma palmitoleic acid,palmitic acid（C18∶1n-9）and MUFA and SCD activity in obese children were significantly higher than those in non-obese children（P0.05）;correlative analysis showed that there was a positive correlation between SCD activity in obese children and BMI（P0.05）.Conclusion：The increases of SCD activity and MUFAs level may play some roles in occurrence of obesity,but the specific mechanisms need to be clarified.