细胞间粘附分子-2在妊娠期高血压疾病患者的动态变化和临床意义

Dynamic changes and clinical significance of ICAM-2 in patients with hypertensive disorder complicating pregnancy

目的:探讨细胞间粘附分子-2(ICAM-2)在正常妊娠妇女和妊娠期高血压疾病患者血浆中的变化及其临床意义。方法:研究对象包括25例妊娠期高血压疾病患者(其中子痫前期13例、妊娠期高血压12例)、24例正常妊娠妇女和25例正常未孕妇女,应用酶联免疫吸附试验(ELISA)测定研究对象妊娠早、中、晚三期血浆中的ICAM-2水平。结果:与未孕组比较,正常妊娠组孕中晚期ICAM-2明显高于未孕组,差异有统计学意义(P<0.05),与正常妊娠组比较,妊娠期高血压组妊娠三期中ICAM-2水平差异有统计学意义(P<0.05),子痫前期组妊娠三期ICAM-2明显高于正常妊娠组,差异均具有统计学意义(P<0.01)。结论:外周血中ICAM-2水平变化与妊娠期高血压疾病密切相关,随着病情加重ICAM-2值明显升高,ICAM-2对预测子痫前期的发生、发展及终止妊娠时机的选择有重要作用;ICAM-2值在正常妊娠中不随孕龄的增长而升高,可能预示不良妊娠结局。

Objective：To explore the changes and clinical significance of intercellular adhesion molecule-2（ICAM-2）in plasma of normal pregnant women and patients with hypertensive disorder complicating pregnancy（HDCP）.Methods：Research objects included 25 patients with HDCP（including 13 patients of preeclampsia and 12 patients of gestational hypertension）,24 normal pregnant women and 25 normal non-pregnant women,the plasma levels of ICAM-2 in the research objects in the first,second and third trimester pregnancy were detected by ELISA.Results：The plasma levels of ICAM-2 in normal pregnant women in the second and third trimester pregnancy were significantly higher than those in normal non-pregnant women（P0.05）;in patients with HDCP,there was significant difference in plasma level of ICAM-2 among the first,second and third trimester pregnancy（P0.05）,the plasma level of ICAM-2 in patients with preeclampsia was significantly higher than that in normal pregnant women（P0.01）.Conclusion：The changes of ICAM-2 level in peripheral blood are related to HDCP closely,with the aggravation of HDCP,the level of ICAM-2 increase significantly,ICAM-2 plays an important role in predicting the occurrence,development of preeclampsia and termination of pregnancy;in normal pregnancy,the increase of ICAM-2 level is independent of gestational age,which may indicate adverse pregnancy outcomes.