乳铁蛋白分子结构及其抗菌机制

Molecular Structure and Antibacterial Mechanism of Lactoferrin

乳铁蛋白是一种单体糖蛋白,是哺乳动物非特异性免疫系统的第一道防线,具有防御微生物感染的功能。分析了乳铁蛋白氨基酸组成、多肽链折叠、铁结合结构、分子表面特性等与抗菌有关的分子结构。综述了乳铁蛋白抗微生物活性的作用机制,包括限制Fe3+利用,抑制细菌生物膜形成,与负电性生物大分子结合,降解细菌毒力因子以及阻止细菌入侵等。

Lactoferrin is a monomeric glycoprotein,which has been considered as the first line defense protein of mammalian nonspecific immune system and involves in protection against microbial infection.Lf＇s antibacterial-related molecular structure,including the amino acid sequence,polypeptide fold,iron binding structure and surface properties were summrized.The antibacterial mechanism was reviewed,including its structure,deprivation of iron,influence of biofilm formation,interaction with macromolecular with negative charge,degradation virulence factors of bacterial and inhibition of bacterial invasion.