气相色谱法测定化妆品中的多元醇保湿剂

Determination of polyol humectants in cosmetics by GC method

建立了气相色谱(GC)同时测定化妆品中5种多元醇(1,2-丙二醇、乙二醇、1,3-丁二醇、二甘醇和甘油)保湿剂的方法。试样用甲醇提取过滤后,采用GC对样品进行定量分析。结果显示,5种多元醇保湿剂的质量浓度与其相应的峰面积呈线性关系,线性范围分别为10μg/mL^1 200μg/mL(1,2-丙二醇和1,3-丁二醇),10μg/mL^1 100μg/mL(乙二醇),10μg/mL^1 000μg/mL(二甘醇),10μg/mL^1 300μg/mL(甘油),相关系数r>0.99。应用此法测定化妆品中5种多元醇保湿剂的质量分数,回收率在93.6%~102.4%,相对标准偏差为0.84%~1.75%。该方法简便快速,结果稳定准确,可用于化妆品中多元醇保湿剂含量的质量控制。

GC method to determine content of 5 humectants including 1,2-propylene glycol,ethylene glycol,1,3-butanediol,diethylene glycol and glycerol in cosmetics simultaneously was established.The samples were extracted with methanol,then filtered and quantitatively analyzed by GC.The linear relationships between values of peak areas and mass concentration of 5 humectants were obtained,with linearity ranges of 10 μg/mL～1 200 μg/mL（for 1,2-propylene glycol and 1,3-butanediol）,10 μg/mL～1 100 μg/mL（for ethylene glycol）,10 μg/mL～1 000 μg/mL（for diethylene glycol） and 10 μg/mL～1 300 μg/mL（for glycerol）.The correlation coefficient is 0.99.Using the proposed method in determination of 5 humectants in cosmetics,the average recovery achieves 93.6%～102.4%,and the RSD achieves 0.84%～1.75%（n=6）.This method is simple,fast,reliable and accurate,and can be used for quality control with respect to the content of polyol humectants in cosmetic products.