摘要
通过分析基因进化过程,以"融合"蛋白产生新功能或新蛋白质为实例,总结出蛋白融合的相关规则,规则包括协同作用、联合作用、多功能组合、多聚体组合和结构域重组等,根据这些规则设计了一个融合蛋白辅助筛选系统,用于融合蛋白规律的探讨以及为蛋白改造和设计提供辅助方案.
To sum up relevant rules of fusion protein,we analyzed gene evolution and took ＂fusing＂ protein which generated new protein and new function as an example.The relevant rules include synergies,joint functions,multifunctional polymer reconstruction and domain shuffling.Based on these ＂regulations＂,we designed an aiding screening system for fusing protem which can be used for studying fusing rules and providing an aiding scheme for protein reform and design.
出处
《昆明学院学报》
2010年第3期62-65,共4页
Journal of Kunming University
基金
昆明学院科学研究资助项目(2007Z007)
云南省教育厅自然科学基金资助项目(07C11655)
关键词
蛋白融合
蛋白质设计
结构域重组
蛋白簇
protein fusion
design of protein
domain shuffling
protein cluster
