大肝癌TACE后肿瘤组织VEGF、αv整合素表达及MVD变化

Expression of VEGF,integrin-αV and MVD in viable residual tumor tissues from large hepatocellular carcinoma after TACE

目的观察大肝癌经导管动脉化疗栓塞(TACE)后残存肿瘤组织血管内皮生长因子(VEGF)、αv整合素表达及微血管密度(MVD)变化的意义。方法 96例大肝癌前瞻性分成术前TA-CE组40例(TACE组)与一期手术组56例(手术组),用免疫组化方法检测96例手术切除标本肿瘤组织VEGF、αv整合素表达及MVD值。结果术前TACE组肿瘤组织VEGF、αv整合素表达免疫反应积分显著高于手术组(分别为P=0.042,P=0.033),MVD两者无显著差异(P=0.103)。结论大肝癌术前TACE促使残存肿瘤组织VEGF及αv整合素的表达增高,有可能促进肿瘤细胞转移。

Objective To investigate the significance of expression of vascular endothelial growth factor（VEGF）,integrin-αV and microvessel density（MVD）in viable residual tumor tissues from large hepatocellular carcinoma（HCC） after transcatheter arterial chemoembolization（TACE）.Methods 96 patients with large HCC were divided to a preoperative TACE group（40 patients） and one-stage operation group（56 patients）.Expression of VEGF,integrin-αV and MVD were examined in all viable residual tumor tissues of 96 patients using immunohistochemical staining.Results There were significant differences in the expression levels of VEGF and integrin-αV between preoperative TACE group and one-stage operation group（P=0.042 and P=0.033）.No significant difference was in MVD between two groups （P=0.103）.Conclusion TACE may enhance expression levels of VEGF and integrin-αV in viable residual tumor tissues from large HCC,and may promote cancer cells to metastasize.