1,25(OH)2D3口服冲击与血液灌流对维持性血液透析患者继发甲状旁腺功能亢进的疗效对比与护理

To compare clinical observation of efficacy of 1,25(OH)2D3 oral pulse and hemoperfusion cure secondary hyperparathyroidism in maintenance hemodialysis patients and nursing

目的:比较1,25(OH)2D3口服冲击与血液灌流对维持性血液透析患者继发甲状旁腺功能亢进(SHPT)的疗效与护理。方法:将维持性血液透析SHPT患者42例随机分成A组[1,25(OH)2D3口服冲击组]及B组(血液灌流组)各21例。A组在1周3次血液透析治疗基础上给予1,25(OH)2D3口服冲击;B组给予1周3次血液灌流串联血液透析治疗。比较治疗后两组血清全段反应性甲状旁腺激素(iPTH)和皮肤瘙痒等改善情况,并探讨护理要点。结果:治疗12周后两组患者iPTH与治疗前相比具有显著性(P<0.01),但B组下降程度较A组更为显著(P<0.01)。结论:血液灌流对维持性血液透析患者SHPT的疗效比1,25(OH)2D3口服冲击更明显,且皮肤瘙痒等症状好转,值得临床推广。

Objective：To compare clinical observation of efficacy of 1,25（OH）2D3 oral pulse and hemoperfusion cure secondary hyperparathyroidism in maintenance hemodialysis patients and nursing.Methods：42 maintenance hemodialysis SHPT patients were radomly divided into group A[1,25（OH）2D3 oral pulse]21 cases and group B （hemoperfusion） 21 cases. Group A accepted 1,25（OH）2D3 oral pulse based hemodialysis three times a week,and group B accepted hemoperfusion and hemodialysis.After treatment to compare two sets of iPTH and pruritus and nursing points.Results：After treatment 12 weeks the iPTH in two groups has significant than before treatment（P〈0.01）, but the decline degree of group B better than group A（P〈0.01）. Conclusion：Hemoperfusion cure secondary hyperparathyroidism in maintenance hemodialysis patients better than 1,25（OH）2D3 oral pulse,improve pruritus, It is worth popularizing.