AnnexinⅡ和NF-κBp65蛋白在胃腺癌组织中的表达意义

Expression and Significance of Annexin Ⅱ and NF-κBp65 Proteins in Gastric Adenocarcinoma Tissues

目的检测胃腺癌组织中AnnexinⅡ、NF-κBp65蛋白的表达,探讨两者在胃腺癌组织中的表达意义。方法用免疫组化S-P法检测33例胃腺癌组织、20例萎缩性胃炎组织和33例胃正常组织中AnnexinⅡ、NF-κBp65蛋白的表达情况,分析其与胃腺癌组织临床病理学特征的关系。结果1)AnnexinⅡ、NF-κBp65蛋白在胃腺癌组织中的阳性表达率分别为81.82%、75.76%,均显著高于萎缩性胃炎组织(45.00%、40.00%)(P<0.05)和胃正常组织(24.24%、15.15%)(P<0.05);2)AnnexinⅡ蛋白在伴有淋巴结转移的胃腺癌组织中的阳性表达率(95.00%)明显高于无淋巴结转移组织(61.54%)(P<0.05),NF-κBp65蛋白在低分化腺癌中的阳性表达率(93.75%)明显高于中高分化腺癌(58.82%)(P<0.05),NF-κBp65蛋白在伴有淋巴结转移的胃腺癌组织中的阳性表达率(90.00%)明显高于无淋巴结转移组织(53.85%)(P<0.05);3)AnnexinⅡ蛋白和NF-κBp65蛋白在胃腺癌组织中的表达呈正相关(r=0.467,P<0.05)。结论Annexin Ⅱ、NF-κBp65蛋白的高表达可能在胃腺癌的发生发展和浸润转移中起重要作用。

Objective To investigate the expression and clinical significance of Annexin Ⅱ and NF-κBp65 proteins in gastric adenocarcinoma tissues.Methods We used the technology of immunohistochemistry S-P methods to detect the expressions of Annexin Ⅱ and NF-κBp65 proteins in the 33 cases with gastric adenocarcinoma tissues,20 cases with atrophic gastritis tissues and 33 cases with normal tissues respectively,and analyzed their correlations to clinicopathologic features of gastric adenocarcinoma.Results 1） The positive expression rates of Annexin Ⅱ,NF-κBp65 proteins in gastric adenocarcinoma were 81.82%,75.76% respectively.It was significantly higher than those in atrophic gastritis tissues（45.00%,40.00%）（P〈0.05） and normal tissues（24.24%,15.15%）（P〈0.05）;2） The positive expression rate of Annexin Ⅱ proteins in gastric adenocarcinoma with lymph node metastasis was 95.00%,significantly higher than that in gastric adenocarcinoma without lymph node metastasis（61.54%）（P〈0.05）.The positive expression rate of NF-κBp65 protein in poor differentiate carcinoma（93.75%） was higher than that in well and moderate differentiated carcinoma（58.82%）（P〈0.05）.The positive expression rate of NF-κBp65 protein in gastric adenocarcinoma with lymph node metastasis was 90.00%,significantly higher than that in gastric adenocarcinoma without lymph node metastasis（53.85%）（P〈0.05）;3） There was a positive correlation between the expressions of Annexin Ⅱ and NF-κBp65 protein in gastric adenocarcinoma tissues（r=0.467,P〈0.05）.Conclusion The high expression of Annexin Ⅱ and NF-κBp65 proteins may play an important role in the occurrence,development,invasion and metastasis of gastric adenocarcinoma.