恩度联合三维适形放疗治疗老年晚期食管癌临床观察

Clinical Observation of Endostar Combined with Three Dimensional Conformal Radiation Therapy in the Treatment of Elderly Patients with Advanced Esophageal Carcinoma

目的观察恩度联合三维适形放疗治疗老年性Ⅲ期食管癌的近期疗效,评价恩度临床应用的安全性和耐受性。方法38例老年晚期食管癌分为两组,分别接受三维适形放疗+恩度(试验组)和单纯三维适形放疗(对照组)。治疗结束后评价疗效和毒副反应。结果试验组有效率为83.3%,临床受益率为100.0%;对照组的有效率为55.0%,临床受益率为90.0%;试验组中位生存期为10个月,对照组中位生存期为7个月。两组毒副反应主要有放射性食管炎、白细胞减少、放射性肺损伤和心脏毒副反应等。结论恩度与三维适形放疗联合应用,能明显提高治疗老年晚期食管癌的疗效,且安全性较好。

Objective To investigate the efficacy and toxicity of endostar combined with three dimensional conformal radiation therapy（3DCRT） in the treatment of elderly patients with advanced esophageal carcinoma.Methods 38 patients with advanced esophageal carcinoma received endostar plus three dimensional conformal radiation therapy（trial group） or three dimensional conformal radiation therapy（control group）.The efficacy and toxicity were evaluated after treatment.Results The trial group＇s response rate was 83.3% while the control group＇s was 55.0%.The clinical benefit rate was 100.0% in the trial group and 90.0% in the control group.The trial group＇s median survival time was 10 month while the control group＇s was 7 month.The main toxicities were radiation esophagitis,leukopenia,radiation-induced lung injury and cardiac toxicity.Conclusion Endostar combined with three dimensional conformal radiation therapy can improve the efficacy of elderly patients with advanced esophageal carcinoma obviously,and the safety is high.