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VEGF与MMPs的相互调节与肿瘤的关系

Relationship of VEGF and MMPs Mutual Regulation with Tumor
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摘要 血管内皮生长因子(VEGF)是一种多功能的糖基化分泌性多肽因子,在多种参与肿瘤血管形成的细胞因子中,它是作用最强、特异性最高的促血管生成因子,因而对于肿瘤的发展起了很大的作用。MMPs是一类锌离子依赖的细胞外蛋白水解酶,可降解基底膜,促进恶性肿瘤细胞的侵袭与转移。它们之间互相调节对于恶性肿瘤的发生、发展更是起了很大的作用。 VEGF is a muhifunctional glycosylated polypeptide secreted factors involved in tumor angiogenesis in a variety of cytokines, and it is a strongest, most specific angiogenic factor,which plays a big role in tumor development. MMPs is a class of extraceUular zinc dependent proteolytic enzymes and can degrade the basement membrane,promoting tumor cell invasion and metastasis. The mutual regulation between the two plays a more important role in the occurrence and development of cancer.
作者 程协慧 刘爱
机构地区 山东省邹城市急救中心 山东省邹城市人民医院
出处 《中国现代医生》 2010年第17期15-17,共3页 China Modern Doctor
关键词 血管内皮生长因子 基质金属蛋白酶 肿瘤 VEGF MMPs Tumor
分类号 R730.231 [医药卫生—肿瘤]
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参考文献19

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二级参考文献7

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中国现代医生
2010年 第17期

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