颅脑损伤患者肌酸激酶同工酶(CK-MB)与病情及预后关系的探讨

The role of serum CK-MB in the clinical diagnosis and prognosis of patients with head injuries

目的探讨颅脑外伤患者血清CK-MB的变化与病情及预后的相关性。方法把80例住院患者分为两组,按GCS3～8分32例为重型组,GCS9～15分48例为轻中型组;于伤后监测血清CK-MB。以健康体检者30例为对照组。按GOS评分为预后良好组、预后差组和死亡组,观察CK-MB与预后的关系。结果 (1)轻中型组、重型组24hCK-MB与对照组比较,差异有统计学意义(P<0.01);轻中型组与重型组比较,差异也有统计学意义。(2)死亡组CK-MB与预后良好组比较,差异有统计学意义(P<0.01)。结论 CK-MB值越高,病情越重,预后越差。提示颅脑外伤患者血清CK-MB活性变化可作为判断病情及预后的参考指标。

Objective To investigate how the diversification of serum CK-MB relate to the clinical diagnosis and prognosis of patients with head injuries.Method 80 patients were divided into two groups：32 patients were selected to be severe group（3≤GCS≤8）;48 patients were selected to be light medium group（9≤GCS≤15）.Their serum CK-MB would be monitored after injured and those cases were divided into good prognosis group,poor prognosis group and death group by GOS score for observing the relationship of CK-MB and prognosis.The control group is composed of 30 healthy people.Results（1）The statistics of CK-MB in 24h of the severe group and the light medium group were compared to that of the control group.The differences among the three groups were significant（P0.01）.And the light medium group was compared with severe group,the differences was statically significant（P0.01）.（2）The difference of CK-MB between Death Group and Good-Prognosis Group was significant（P0.01）.Conclusions As a result,higher CK-MB reflects that the patient＇s clinical condition is more severe,and the prognosis is worse.The change of active serum CK-MB can be a reference to the clinical diagnosis and prognosis of patients with head injuries.