宽叶大戟化学成分的研究

Studies on the chemical constituents from Euphorbia latifolia

目的研究宽叶大戟的化学成分。方法采用硅胶柱层析法、Sephadex LH-20凝胶柱层析法,对宽叶大戟全草体积分数95%乙醇提取物的氯仿萃取部分进行分离,根据理化性质和波谱数据确定各化合物的结构。结果分离并鉴定了8个化合物,分别为:三十二烷酸(1)、蒲公英醇(2)、α-波甾醇(3)、羽扇豆醇(4)、β-谷甾醇(5)、白桦酸(6)、齐墩果酸(7)和桦木醇(8)。结论化合物1-4为首次从宽叶大戟中分离得到。

Objective To investigate the chemical constituents from Euphorbia latifolia.Methods The constituents of CHCl3-soluble portion of 95% ethanol extract were isolated and purified by repeated chromatographies with silica and Sephadex LH-20.Compounds were identified by their physical characteristics and spectral features.Results Eight compounds were isolated and identified respectively as lacceroic acid（1）,taraxasterol（2）,α-spinasterol（3）,lupeol（4）,β-sitosterol（5）,betulinic acid（6）,oleanolic acid（7） and betulin（8）.Conclusion Compounds 1-4 were isolated from this plant for the first time.