利妥昔单抗致不良反应325例文献分析

Literature analysis of 325 cases of adverse drug reactions of rituximab

目的探讨抗肿瘤靶向药物利妥昔单抗(美罗华)不良反应的特点及规律,为临床安全、合理用药提供参考。方法采用回顾性研究方法,利用中国期刊全文数据库对1999～2009年报道的利妥昔单抗不良反应病例进行统计分析。结果不良反应主要为输注反应,且主要出现于第1次静脉滴注。结论使用利妥昔单抗治疗应严密监护,保证用药安全。

Objective To investigate the adverse reactions of rituximab（Rituxan and MabThera） in retrospection to provide references for safe and rational drug use clinically.Methods A retrospective analysis was conducted on adverse reactions of rituximab during the period from 1999 to 2009 retrieved from CNKI database.Results The main ADRs were infusion reactions,and occurred mainly in the first intravenous drip.Conclusion The use of rituximab treatment should be closely monitored to ensure the safety of drug use.